Toxic Astrology Ex-Best Friends follows Arla and Emmie, two girls who share everything: They’re both trans, they love witchcraft and astrology, and they cohost a podcast to help other queer people with their relationship problems. But all is thrown into question when Arla realizes that, for the first time, she has a secret she can’t talk about on mic: She has a crush on Emmie. Will their friendship survive?